Studies of Respiratory as well as Circulatory Effects and Pathological Changes of Fluothane, Fluothane-Ether Azeotropic Mixture and Chloroform Anesthesia in Dogs

Abstract

Fluothane, Azeotrope and Chloroform were administered to 94 dogs with a copper kettle vaporizer in a non-rebreathing system.
1) Intravenous administration of epinephrine and nor-epinephrine produced fatal ventricular fibrillation in dogs anesthetized with Fluothane, Azeotrope and Chloroform.
2) Arrhythmia induced by epinephrine during Fluothane, Azeotrope and Chloroform anesthesia was prevented by Trilafon (Perphenazine) injection prior to epinephrine injection. Dibenamine also prevented arrhythmia induced by epinephrine during Fluothane and Azeotrope anesthesia.
3) There were significant differences between the preanesthetic level of respiratory minute volume, blood pH, Pco₂, HCO₃, and those observed during Fluothane, Azeotrope and Chloroform anesthesia in various concentration. Anesthesia under Azeotrope showed least alteration in acid-base balance compared with anesthesia under Fluothane and Chloroform.
4) Blood pressure lowered in proportion to increased concentration of Fluothane, Azeotrope and Chloroform inhalation. Extrasystole in EKG was observed in a single dog anesthetized wiht Chloroform although no significant changes in EKG were observed in dogs anesthetized with Fluothane and Chloroform.
5) Diffuse fat degeneration of liver cells was seen in all dogs administered Chloroform, but minimum alteration in the composition of liver was seen in dogs administered Fluothane and Azeotrope.