Electroencephalographic Study of Action of Central Stimulant on Pentobarbital Anesthesia

In Special Reference to Accelerating Action of Cardiazol on Pentobarbital Anesthesia

Abstract

The actions of cardiazol and megimide injected intravenously on pentobarbital anesthesia were investigated by righting reflex test and by electroencephalographic technique with rabbits.
1) Megimide exerted remarkable antagonistic action in subconvulsive as well as convulsive dose to pentobarbital anesthesia in rabbit. Cardiazol had similar action in convulsive dose to that of megimide. If the subconvulsive dose of cardiazol was administered to pentobarbital anesthetized rabbit, the depth of anesthesia was increased and no antagonistic action was seen after cardiazol in this case.
2) In light pentobarbital anesthetized rabbit, cardiazol caused characteristic EEG pattern with high voltage slow wave component simultaneously developed in cortex, hippocampus and centre median nucleus of thalamus.
3) The accelerating action of the small dose of cardiazol on pentobarbital anesthesia might be related to the slow wave component in cardiazol EEG pattern picked up from hippocampus as well as centre median nucleus.