Abstract
The permeability of blood vessels of the connective tissue, omenta and caeca of mice injected intravenously with an India-ink solution made by normal fresh horse serum was studied before and after subcutaneous injection of drugs; Spa, guaiazulene, diphenhydramine and acetylsalic acid. In addition, the protective effects of these drugs on gastric ulcer were examined, using Shay rat.
The results were as follows in summary.
1) Guaiazulene in small doses had marked depressive action on the increased permeability of venules inflamed by horse serum. Spa and diphenhydramine acted similarly to guaiazulene on the walls of venules, but weaker than the latter drug. Acetylsalicylic acid had no significant effect.
2) Guaiazulene, Spa and diphenhydramine exerted protective effects on the gastric ulcer after the subcutaneous administration of large doses of the drugs, but acetylsalicyic acid administered subcutaneously showed slight protective effect in large doses upon the gastric ulcer of rat.
