Effct of Histamine on Tissue Inulin Space in Rabbits

Abstract

The effect of histamine on inulin spaces of various tissues such as lung, cardiac muscle?liver, skeletal muscle, intestine and spleen were studied in rabbits.8 normal rabbits wereused as control and on 8 rabbits effect of histamine was observed.
Rabbits of both groups were nephrectomized in the same day of experimentation.
Inulin was administered intravenousely. Total inulin space was easured after 2 hours of equilibration.
Blood samples were collected at every 30 minutes and assayed for inulin. Tissue inulin_space, expressed as tissue inulin concentration (mg/ml)/Plasma inulin concentraton(mg/gm)×100, varied tissue to tissue, The order of magnitude of tissue inulin space was lung, cardiac muscle, spleen, skeletal muscle, intestine and liver.
Histamine produced decrease of tissue inulin space as well as total body inulin space as. compared to control.