Studies on the non-specific hyaluronidase inhibitor in serum

Report I Biological test

Abstract

1. Non-specific hyaluronidase inhibitor in the rabbit serum increased in both cases of bacterial and non-bacterial infections, and the values of inhibitor related to the degree of general emaciation rather than to that of inflammatory reactions.
2. This fact suggests that the increasing of the inhibitor was caused by tissue destruction.
3. Heparin inhibited hyaluronidase activity in vitro, however heparin adding serum did not show this inhibitory effect. In vivo, too, heparin showed no inhibi t i on to the enzyme.