Application of Duvadilan for Ocular Diseases
1965 Volume 17 Issue 4 Pages 379-385
Details
1965 Volume 17 Issue 4 Pages 379-385
Isoxsuprine (1- (P-hydropheny1)-2-(1'-methyl-2'-phenoxy-ethylamino) propano1monohydrochloride (Duvadilan) was pharma-cologically Investigated and was appnea for 23 cases of ophthalmological patients suffered from occulsion of retinal arteries (3 cases), central chorioretinitis (6 cases), sclerosis of retinal central arteries (5cases), diabetic retinopathy (4 cases) and atrophy of optic nerve (5 cases).
Isoxsuprine is adrenergic, but has vasodilatative effect due to its adrenergic betaeffect, which was shown in animal experiments in this paper.
The effect of this drug on patients was symptomatical and it was used to improve the blood supply of retinal tissue which had been fallen in ischemia induced by above mentioned diseases. Though retinal arteries were dilated after intramuscular administration in dose of 5 mg, the cure effect was indistinct, but the drug was more useful and safe than any other vasodilator: amil-nitrit, imidaline or carnige n which has been recommended on these diseases.
