Electrophysiological Studies of the Action of Cardiazol on Barbiturate Anesthesia

Abstract

It is generally accepted that the anesthetizing time of rabbits by barbiturate is prolonged when a certain amount of cardiazol is administered.
In this experimentation, we studied the effects of these drugs on the action potential in the central nervous system.
The arousal reaction both on the cerebral cortex and hippocampus which develops following the stimulation of the brain stem reticular formation was not affected by cardiazol administration (10 mg/kg, i. v. ) after barbiturate (10 mg/kg, i. v. ).
Following the above-mentioned experiment, we examined the effects of drugs on recruiting response which appeared after the stimulation of then. centrum medianum and then. ventralis anterior.
It was revealed that recruiting response to these nuclei showed different susceptibility according to the agent administered. A series of experiments of n. centrum medianum have demonstrated a trend of increase in recruiting response following the administration of cardiazol. However, recruiting response in the case of the n. ventralis anterior was depressed after cardiazol administration.
From the above results, it may be safely asserted that what directly concerns the loss of senses is n. centrum medianum, and not n. ventralis anterior, and that n. ventralis anterior plays an important role in the development of recruiting response wave; in other words, that function is apart from wave form.