Abstract
Included are studies of acute toxicity, subacute and chronic toxicity and photosensitizing activities. The results are summarized as follows.
1) A daily dose of trioxsalen of less than 10 mg per kg body weight could be orally given in rats for periods up to six months without apparent toxic effects.
2) In the presence of ultraviolet radiation, trioxsalen and 8-methoxypsoralen evoked changes on the skin of guinea-pig manifested by erythema, and two drugs possessed almost same photosensitizing activities in the case of a local administration in a concentration of 10-3 to 10-2g per ml or in the case of an oral administration in a dose 5 to 10 mg per kg of body weight.
