Abstract
Fourteen suspected cases of drug-induced hepatitis were diagnostically confirmed by determinating serum enzyme activities following provocative readministration of causative agents.
After recovery of their clinical course, the 14 cases were readministrated about half a daily dose of their respective causative agent. Then, the activities of several seru m enzymes were chronologically determined. In 24-48 hours, all cases showed a marked increase in glucose-6-phosphatase, isocitric dehydrogenase and aldolase.
Rabbits with experimental liver injury induced by 2-hydroxy-methylene-17 α-methyldihy-drotestosterone showed almost identical results in serum enzyme activities as with those of human cases.
Comments are made on the sorts of inducing drugs, incubation periods, symptoms and signs, clinical course, laboratory data, histological findings in liver biopsies, diagnosis, treatment and pathogenesis of drug-induced hepatitis.
