Electroencephalographical investigation of antiepileptics

- On the spectrum of the antagonistic actions of antiepileptics against experimental seizure disc harges -

Abstract

Electroencephalographical investigations of antiepileptics against four kinds of afterdischarges and three kinds of chemically-induced seizure discharges were carried out in order to predict their clinical efficacy or selectivity for various types of epilepsy. In connection with the chemically-induced seizure discharges, separately from the above experiments, the author also investigated the effects of the convulsant drugs on EEG to clarify their sites and modes of actions in CNS. The following results were obtained.