1978 Volume 30 Issue 2 Pages 223-231
The interactions between antibiotics, Evans blue, and serum protein were measured by the ultracentrifuge (300,000 X gravity) method. In addition, the effects of antibiotics on blood coagulation (prothrombin time, and partial thromboplastin time). platelet function (aggregation and adhesiveness), and electrolyte (Na, and K) were also observed. The results were as follows:
1) No interactions be tween antibiotics, Evans blue, and serum protein were seen.
2) No antibiotic influences on prothrombin time and partial thromboplastin t ime could be found.
3 ) No antibiotic influences on platelet aggregation and adhesiveness were present.
4) Electrolyte Na was slightly elevated by antibiotics (400mg/kg i. v. ), bu t electrolyte K was slightly lowered by the same ciosage. No antibiotic influence on electrolytes were shown by the lower dosage (9mg/kg).
The results reported in P arts I, I I, and III suggest that antibiotics may increase capillary permeability, which may be the cause of their increasing concentration in the tissues and their changing rates of concentration (tissue/blood) following i. v. administration.
