An Electrophysiological Study on the Effect of Stimulation on Olfactory Bulb
1982 Volume 34 Issue 1 Pages 1-46
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1982 Volume 34 Issue 1 Pages 1-46
In order to elucidate the possible influence of smell on living organisms, electrical stimulations were given on the olfactory bulb of rabbit both at high and low frequencies. Following are the effects observed.
1. The threshold of arousal reaction and muscular discharges evoked by the RF (reticular formation) stimulation were elevated significantly. The elevation was more remarkable when stimulated at low frequency.
2. The number of RF unit discharges decreased with the stimulations both at high and low frequencies.
3. The muscular discharges evoked by the stimulation on cerebral cortex were inhibited at low frequency, but at high frequency, they showed no remarkable change.
4. The effect on the muscular discharges evoked by the stimu lation on hippocampus was both facilitatory and inhibitory at either frequency.
5. The effect was facilitatory on both cortical and hippocampal average potentials evoked by the stimulation of sciatic nerve. The facilitatory effect was remarkable on the cortical evoked potentials when stimulated at high frequency, and so was it on the hippocampal evoked potentials at low frequency.
6. The effect was inhibitory on the nociceptive reflex and the M-H wave. It was prominent when stimulated at high frequency.
7. The carotid as well as the femoral blood flow was not affected remarkably.
8. The effect on the intestinal movements was facilitatory at low fr equency, whereas it was an inhibitory one when stimulated at high frequency.
9. The uterine movements were influenc ed in a facilitatory way at high frequency.
10. Barbiturate suppressed all the effects above described.
11. The several kinds of smell samples showe d different effects from each other on the intestinal movements.
12. On the potentials of amygdala evoked by the stimulation, both barbiturate and chlorpromazine showed inhibitory effect while on the contrary, both predonine and TTFD showed facilitatory effect. Morphine, ATP and CDP-choline had no significant effect.
In conclusion, we tried to make it clear using rabbits how the olfactory system can affect the living organism, and also suggested that some chemicals could be of use for the treatment of central dysosmia.
