1982 Volume 34 Issue 4 Pages 1006-1021
In order to assess the hemodynamic effects of OP-1206, oral prostaglandin E1 derivative,7healthy controls and 48 patients (20 with essential hypertension,11 with old myocardial infarction,7 with acute myocardial infarction and 10 with atrial fibrillation) were studied at rest and 60 minutes after oral administration of the drug (30, μg).
Hemodynamic studies were made by means of impedance cardiography, echocardiography and Swan-Ganz right heart catheterization technique. Brachial arterial pressure was measured by the air-cuff method. Left ventricular function curves were constructed for in patients with atrial fibrillation: preceding R-R intervals and stroke volumes computed from impedance cardiogram were plotted on x and y axes, respectively.
The healthy control group sho wed significant decrease in mean systemic arterial blood pressure by 7% without any significant changes in heart rate, cardiac index and total peripheral resistance index. In the hypertensive group, the mean arterial pressure decreased by 14%, cardiac index increased by 13% and the resistance decreased by 23%. In the patients with old and acute myocardial infarction, mean arterial pressure decreased by 8-13%, cardiac index increased by 14-19% and the resistance decreased by 17-28%. However, no significant change in heart ra te was observed in these groups. No significant changes in left ventricular end-diastolic and endsystolic volumes were demonstrated in the hypertensive group. In the patients group with acute myocardial infarction, pulmonary diastolic pressure showed significant decrease by 21%; this reduction of left ventricular filling pressure was considered to be secondary to afterload reduction to the left ventricle by vasodilating effect of OP-1206. The maximum hemodynamic effects of the drug were observed within an hour and the effects continued four hours or more from op-1206 (30μg) administration.
The circulatory changes observed in this study indicate that prostaglandin E1 derivative, OP-1206, has a vasodilating and/or antihypertensive effect. The drug is considered to be effective and benefical against hemodynamic state with excessive afterload to the left ventricle.
