"Fosterage Experiments" and Other Supplementary Experiments Related to Ferric Nitrilotriacetate (Fe-NTA) -induced "F1 Amyloidosis"

Abstract

ICR/JCL strain mice used were divided into 3 groups ( I, II and III ) which were treated as described in a chapter of materials and methods.
The results from groups I, II and III suggest that because of immunological memory for the antigen (Fe-NTA conjugate) remaining in the F₁ mouse blood as a result of maternal transmission of the antigen via the placenta, the F₁ mice given Fe-NTA chronically may have responded much more strongly with the same antigen than their maternal mice, eventually leading up to macrophage dysfunction to synthesize amyloid fibrils.