Studies on Causes Inducing Positive Reaction in Self-Controls of Coombs Tests Carried Out as Cross-Matchings and on Transfusion Results in These Cases

Abstract

Self-control of indirect Coombs tests gave positive results at the frequency of 5.5% (585cases) among 10,727 pretransfusion cross-matchings. Drugs (antibiotics, methyldopa) (46.3%), adsorption of complement along with anti- I (17.8%), autoantibodies (3.6%), and anti-A or anti-B (0.7%) were the main causes of these positives. On the other hand, no such causes could be found in the remaining 30.8%.
In the 460 cases who received blo od transfusion in spite of their positive self-controls, no clinical side effects were obserevd.