Studies on the Irreciprocal Conduction of Excitatioa.

Report III. On the Conduction of Excitation upon the Neuromuscular Junction.

Abstract

From a standpoint of conduction of excitation and its direction, the livingsystems can be classified into three fundamental conduction systems of excitation (“Typical Isodromical System”, “Atypical Isodromical System” and “Heterodromical System”). The author verified in the previous report that this fundamental conduction systems of excitation were demonstrated in the conduction of excitation between the atrium and ventricle.
In this paper, it has been verified on the neuromuscular junction whether the above fact is applicable to the livingsystems besides the atrioventricvlar aspect.
Method: - Kiihne's M. Sartorius method was followed.
Result: - The conduction of excitation upon the neuromuscular junction showed an irreciprocal conduction of excitation under the normal condition, but showed a reciprocal condition (e. g. with Adrenaline-Ringer's solution). The latter conduction changed into an irreciprocal conduction following a change in the condition (e. g. was used instead of Adrenaline-Ringer's solution Ergotoxine-Ringer's solution).
It was verified that the three fundamental condition systems of excitation were reversible serially.
The results were the same with conduction of excitation in which a eptum was the only bridge between the atrium and ventricle.
Accordingly the results do not agree with the so far accepted maintance that the conduction upon the neuromuscular junction is irreciprocal.