Abstract
It surely follows death to give a complete bilateral adrenalectomy to any animals. Various methods were tried to make rabbits with impaired adrenalglands survive persistent stimuli. The most successful method is a removal of one adrenal gland with ligature performed to the nutritional blood vessels of the other gland. This method afforded comparatively few chances of life hazard to the animals. On rather strong stimuli such as a decrease in temperature, fastening their bodies to a fixing board or drawing of blood, the animals fell into fatal shock. It is considerd that these animals showed a decreased enviromental adaptation. Namely, it seemed that the operated rabbits whose remaining adrenal gland was not sufficient to sustain their lives often developed such fatal shock as found in complete adrenalectomized ones. However, it must not be noted that the adrenal gland whose blood vessels is ligated, can regenerate. The aninals were re-operated on to examine whether their ligated adrenal gland had regenerated or not, at the end of the experiment. It was found that inflammatory reactions (in comparison with the control animals) were depressed when the adrenal gland had not yet regenerated, while the reactions were not depressed when the adrenal gland had regenerated, the animals employed must be male adult rabbits weighing 2 to 3 kg never premature or senile. For their survival the rabbits must be always injected with a large amount of normal saline solution. Thus, the treated rabbits can survive persistant stimuli without being administered with DOCA and/or ACE, eyed if they have a very small portion of the adrenal gland.
