Abstract
The Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic
Cardiovascular Diseases （JASGL） were based on “the lower, the better” hypothesis.
However, we published Cholesterol Guidelines for Longevity 2010 based on the
fact that cholesterol levels are inversely associated with all-cause mortality among
general populations aged at 40 years and over. Here, we summarized the mechanisms
of atherogenesis caused by statins and some types of vegetable oils with strokestimulating
activity in the rat; they inhibit the VK1-VK2- osteocalcin target organs
link, leading to artery calcification and lifestyle-related diseases. The mainstay of
JASGL 2017 is the Suita study published in 2014, which is much smaller than the
previous epidemiological study, NIPPONDATA 80, for JASGL 2012. Besides, the total
and cardiovascular mortality of the study has not been published yet. We found some
terrible mathematical errors that cannot be simple calculation mistakes. For example,
deleting some study subjects actually increased the number of male participants
instead. It is likely that no consistent epidemiological studies are available any more
to JAS to protect their cholesterol hypothesis. JASGL 2017 calculated risk of coronary
artery disease （CAD） in Japan where the incidence is very low. Then the story was
fabricated to protect their notion that even the group with a very low risk in the
world standard was classified as middle to high risk groups of CAD, which can lead
to unnecessary medication. The GLs are disguised as those based on the cholesterol
hypothesis; actually it became very clear that they are simply selling tools for statins.
