Abstract
We performed the maggot therapy using by medical aseptic larvae for refractory wounds in clinical fields of Japan, and furthermore we established the bioventure business to develop and spread the maggot therapy in Japan. The maggot therapy has great debridement effect, and is very effect to infectious wounds for antimicrobial peptides etc. And so the maggot therapy will get the great effect of reducing the wound healing periods to growing up the healthy granulation for very short time. We also developed the maggot bag of high molecular compound which first maggots never escape from bag, second can’t see the maggots from outside, third less feel pain, fourth easy to attach and remove the bag. In our department the results of maggot therapy in 159 cases are 91.8% of the limb salvage rate, and 91.2% of survival rate in 7.1±0.2 years of mean follow-up periods. Especially the diabetic foot gangrene without peripheral arterial disease (PAD) is very effect and safe with any events and troubles. The maggot therapy is a novel wound treatment which everybody can perform easily, except out of national health insurance.