Abstract
We show that a handlebody-knot whose exterior is boundary-irreducible has a unique maximal unnested set of knotted handle decomposing spheres up to isotopies and annulus-moves. As an application, we show that the handlebody-knots 614 and 615 are not equivalent. We also show that certain genus two handlebody-knots with a knotted handle decomposing sphere can be determined by their exteriors. As an application, we show that the exteriors of 614 and 615 are not homeomorphic.