Living-donor liver transplantation: present status and future perspective

Mitsuo Shimada; Masahiko Fujii; Yuji Morine; Satoru Imura; Tetsuya Ikemoto; Hiroki Ishibashi

doi:10.2152/jmi.52.22

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Living-donor liver transplantation: present status and future perspective

Mitsuo Shimada, Masahiko Fujii, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Ishibashi

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Keywords: Adult-to-adult living donor liver transplantation, small-for-size graft, large-for-size graft, hepatocellular carcinoma, ABO blood-type incompatible transplantation, marginal donor, hepatitis C, fatty liver, age

JOURNAL FREE ACCESS

2005 Volume 52 Issue 1,2 Pages 22-32

DOI https://doi.org/10.2152/jmi.52.22

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Abstract

About 15 years have passed since the first liver transplant from a living donor (living donor liver transplantation: LDLT), and the status of the procedure has since been established as a standard cure for end-stage liver disease in Japan where liver transplantation (LTx) from deceased donors has not yet been accepted. However, the following problems are surfacing with the increase in the number of LDLTs between adults: graft size mismatching, an ABO blood-type incompatible transplantation, the expansion of LDLT indication to hepatocellular carcinoma (HCC), the relapse of hepatitis C after LDLT, marginal donors, and the freedom from immunosuppressive treatment. In this article we outline the present conditions of these problems and the future view of the LDLT. J. Med. Invest. 52: 22-32, February, 2005

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