The Journal of Medical Investigation
Online ISSN : 1349-6867
Print ISSN : 1343-1420
ISSN-L : 1343-1420
Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study
Tamae NishiEmi ShutoMariko OgawaMiho OhyaMisaki NakanishiMasashi MasudaMisaki KatsumotoHisami Yamanaka-OkumuraTohru SakaiEiji TakedaHiroshi SakaueYutaka Taketani
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2015 Volume 62 Issue 3.4 Pages 167-172


Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h,while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. J. Med. Invest. 62: 167-172, August, 2015

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© 2015 by The University of Tokushima Faculty of Medicine
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