2025 Volume 72 Issue 3.4 Pages 245-251
Background:The number of elderly patients with frailty who require hepatectomy is increasing. This study aimed to investigate the effect of Ninjin’yoeito (NYT) on the post-hepatectomy state in naturally aged frailty model mice. Methods:Seventy-two-week-old mice were subjected to 70% partial hepatectomy and then divided into an NYT-treated group and a control group. Mice were sacrificed immediately (0 hours) or 24 or 48 hours after hepatectomy. Body weight, grip strength, endurance, and survival duration were investigated. Furthermore, liver function was assessed, and mRNA expression was measured using reverse-transcription PCR. Results:The body weight tended to be higher in the NYT group than in the control group 24 hours after hepatectomy (p=0.09). The grip strength was significantly stronger in the NYT group before and 48 hours after hepatectomy (p<0.05). Although survival time was slightly prolonged in the NYT group, there was no significant difference between the two groups. HMGB1 mRNA expression in the liver was significantly suppressed in the NYT group compared with that in the control group at 24 and 48 hours after hepatectomy (p<0.05). Conclusions:NYT may affect the postoperative state, including body weight and motor function, in aged model mice. Suppression of HMGB1 might affect postoperative survival. J. Med. Invest. 72 : 245-251, August, 2025
