Differences in associations of follicle-stimulating hormone with lipid profiles according to oral and transdermal hormone replacement therapy in Japanese women during the menopausal transition

Abstract

Background and aim:The associations between follicle-stimulating hormone (FSH) levels and lipid profiles have been controversial. The aim of this study was to examine the associations between FSH levels and lipid profiles before and during hormone replacement therapy (HRT) in Japanese women. Subjects and methods:We recruited 117 women who were receiving HRT and examined serum levels of FSH, LH, estradiol, triglycerides (TG), LDL-C and HDL-C. In addition, the associations of reduction rate of FSH and increase in estradiol level with changes in lipid parameters before and during HRT were examined. Results:FSH showed a significant negative correlation with TG and LDL-C and a significant positive correlation with LH and HDL-C. In women receiving oral estrogen, the rate of increase in HDL-C and TG was significantly greater in the group with a large decrease in FSH. In women receiving oral estrogen, LDL-C was significantly decreased and TG was significantly increased in the group with a large increase in estradiol. Conclusion:We demonstrated associations between FSH level and favorable lipid profiles in this study. During HRT, the action of reduction of FSH on lipid parameters did not exceed the direct action of estrogen. J. Med. Invest. 72 : 290-297, August, 2025