The evaluation of efficacy for laparoscopic assisted microwave coagulation therapy for the patients of hepatocellular carcinoma with poor liver function

Abstract

We have already reported the safety and efficacy of laparotomic microwave coagulation therapy (LMCT) for the patients of hepatocellular carcinoma (HCC) with impaired liver function. The aim of this study is to evaluate less invasiveness of laparoscopic assisted microwave assisted microwave coagulation therapy (LAMCT) compared with LMCT.
Method : 18 patients of HCC with poor hepatic reserve underwent since April, 2001. 7 patients received LAMCT (LA group) and 11 patient received LMCT (L group). Clinical data ware analyzed before and after surgery in 18 patients.
Results : Operative time, blood loss during surgery, and hospitalization were significant less in the LA group than those in the L group. No significant differences between the groups were recognized after surgery in regard to changes in the time course of levels of liver function (AST, ALT, Total bilirubin, Prothrombin time, and Albumin). The changes in the time course of levels of WBC and CRP, as postoperative inflammatory indicators, in the LA group were significantly lower than those in the L group (p<0.05).
LAMCT might be useful treatment mordality for the patient of HCC with poor liver function, whose tumor number is not multiple and tumor size is 3cm or less, and further more, tumor location is not adjacent to Glissonn's sheath.