Birth of ng/fg Parthenogenetic Mouse

Abstract

In mammals, both maternal and paternal genomes are required to accomplish normal development to term, because parent-specific epigenetic modification of the genome is imposed during gametogenesis. This leads to inequivalent expression of imprinted genes sorely from the maternal and paternal allele. Production of a viable parthenogenetic mouse individual proved that genomic imprinting governs mammalian ontogeny.