2018 Volume 4 Issue 1 Pages 14-19
Temozolomide (TMZ) is used for postoperative standard chemoradiation regimen against malignant glioma but we sometimes have no other choice but to intermit or withdraw the drug due to its hematological toxicity. One of the Kampo or traditional herbal medicine, juzentaihotou (JTT) is reported to be effective against cytopenia in combination with some anticancer drugs for solid cancers, but no report is available with regard to the effect of JTT in combination with TMZ. This study investigated the efficacy of JTT for bone marrow suppression during TMZ induction course. 3 cases were administered JTT when the trend of neutrophil, lymphocyte or platelet decreased to a certain level during TMZ induction course. As a result, the cell counts were generally increased to 132% in neutrophil, 130% in lymphocyte and 120% in platelet after the first week of JTT administration. All of 3 cases completed TMZ induction course without discontinuation. Conclusion: JTT reduces cytopenia caused by TMZ and it may contribute to complete induction course without discontinuation of TMZ.
