Abstract
Previously the mechanisms involved in nasal allergy was considered that allergic reaction in the submucosa of nasal mucous membrane only is responsible for symptoms which are a product of direct action of chemical mediator released to the target tissues, Against the above concept, however, the present paper demonstrated an important role of allergic reaction on the airway surface and reflectory effect of the chemical mediator on effector cells in nasal manifestation.In other words, nasal allergic manifestations could be produced without allergen penetration into the submucosa and without direct stimulation to the submucosa.
Soluble allergic substances are eluted from allergen particles in the mucous blanket and then produce a chemical mediator release from both the blood basophils, which emigrate from the circulation to the mucous blanket and the mast cells, which move in the epithelial layers.The mediator thus released is sufficient in amount to induce nasal manifestation.It is absorbed quickly and thence stimulates the endings of the trigeminal nerve colse to the basement membrane of the epithelial layer.This stimulation results in production of sneezing and watery secretion through the nervous pathway reflex.On the other hand the mediator stimulates directly to the blood vessels in the submucosa, resulting into nasal obstruction.
