Abstract
Sera from 834 persons aged 0-68 years including cord bloods were collected in 1977-1979 at different areas in Thailand by Society for Medical Research in South East Asia, Nippon Medical S chool. These sera were examined by micro complement-fixatio (CF) test for antibodies to cytomegalovirus (CMV) and by micro neutralization (NT) test for antibodies to herpes simplex virus (HSV) type1 & 2. However, NT antibody titers were analyzed by using the II/I index in order to determine the type of HSV antibodies, because there is cross-reaction between type1 & 2 viruses.
(1) Age related CMV antibody positive persentages were79. 2% of all samples, 91.1%incord bloods, 46.7%at the age of 7-11months old, 74.1%of7-8years old, 75.3-85.9% up to 30 years old, 95.5% of older than 31years.
(2) Comparing the age related CMV antibody positive rates of different areas, it was recognized that all sera from the5-63years old of a hill tribe villege had the positive antibodies, and the antibody positive rate apparently decreased in accordance with the advance of urbaniza.-tion of the areas especially among adults. Sera with high titers of the antibody were found in all age groups in Bangkok, which suggested dense infection within small groups of low socio-economic status.
(3) In 33 paired serum samples from mother and newborn (cord blood), CMV antibody status corresponded well, each other. However, the antibody positive rate in mothers was higher than that of average adults. This suggested that latently infected CMV in the female was reactivated during pregnancy.
(4) Analysis with II/I index showed that HSV antibody was contained in 62.7% of all samples, 87.5% in cord bloods, 5.9% at the age of0-6 months old, 52.6%of 3-4 years old, 52.6-63.2%up to 20 years old, and 70.8%of 21-25years old.
Increase of HSV seronegative young adults has recently attrated attention in the developed countries, but this tendancy was not yet recognized in Thailand.
(5) By using the II/I index, NT antibody to type1was found in about10%of children below 2 years old and about 50% of 3-10 years old. On the contrary, type 2 antibody was found in 10% of 3-20 years, and 18% of over 21 years old.
(6) Although antibody status by age was somewhat different in different geographical areas, primary infection of HSV was supposed to occur in higher ages in Bangkok compared to another rural areas.
(7) Thirty-three pairs of sera from mother and newborn were analysed with II/I index. Type1antibody was found in both samples of 21 pairs, and4pairs were antibody negative. In 8pairs, mother and newborn antibodies were not identified as same type, but the difference of NT antibody titers between mother and newborn were less than 2 times, except 2 pairs.
