Abstract
The inhibitory effect of Lecithin-bound Iodine (LBI) on allergic reactions and immune responses in animals was studied. The results are as follows.
1) The pretreatment of 20 mg/kg of LBI induced inhibitory effects on heterologous and homologous PCA in the guinea pig and the rat.
2) The protective effect on the passive systemic anaphylactic shock and passive Arthus reaction in the guinea pig by the pretreatment of LBI was hardly noticeable.
3) The pretreatment of LBI was not effective in suppressing IgM and IgG antibody production. However, the production of IgE antibody in mice was slightly inhibited by the injection of LBI.
4) The inhibitory effect of LBI on the delayed-type allergic skin reaction in the guinea pig was dearly observed.
These results suggest that LBI may be useful in the clinical trial against type I allergic diseases and/or in some cases of auto-immune diseases.
