Abstract
It is generally said that prostatic cancer is a hormone-dependent tumor which produces acid phosphatase (ACP) and that the amount of ACP parallels the spread of the cancer.
However, since the relationship between sex hormones and the increase in ACP is as yet obscure and the cancer is sometimes hormone-independent, there exists confusion in its treatment.
In order to establish the basic knowledge of treatment for prostatic cancer, we have carried out biochemical and histochemical investigations of ACP activity using established cell lines of human prostatic cancer and examined effects of sex hormones on cell growth.
The established cell lines from human prostatic cancer, such as Duke 145, 8 PC 93, and 19 PC 93, were employed. They were examined for increasing ACP activity and for sensitivity to sex steroid hormones. The results obtained are as follows.
