Abstract
An i . v. administration of syngeneic spleen cells (SPCs) caused the functional change of splenic adherent cells (SACs).
The antigen presenting activity of the SACs reduced partly by i.v. injection of 5x107 antigen pulsed or non pulsed SPCs 10 days before. This reduction was not canceled by cyclophosphamide treatment which would eliminate suppressor T cells. Therefore suppressor T cells do riot seem to participate in this phenomenon, while the complete mechanism of this reduction is not clear. On the other hand, when mice were injected with the syngeneic spleen cells, followed by an immunization 6 days after to induce suppressor T cells, a reduction of antigen presenting activity occurred in the SACs only in the group of mice injected with antigen pulsed SPCs. The recovery from this reduction was made possibly by cyclophosphamide treatment. So, suppressor T cells might play an important role in reducing the antigen presenting activity specifically to the antigen on injected. SPCs.
