Abstract
When hemorrhagic shock occurs, it is necessary to await the further clarification of its pathophysiology. This communication deals with a correlative study of the ultrastructure of the lung as well as the biochemical characterization of surfactant materials.
A particular attention should be paid to the ultrastructual changes of the micro-circulatory system in the alveo-capillary spaces. In fact aggregate and adherent of the platelets and white blood cells in the capillary wall would play a very important role in causing the "shock lung" and the careful investigation has been carried out in this context.
The results obtained are as follows :
1) The TBA reaction substance was increased, according to the interval of each shock, which appeared to correlated with the increase in number of the neutrophil in BAL.
2) The β-glucuronidase was significantly elevated in the serum, which appeared relavant to the degradation of alveolar macrophage according to the hemorrhagic shock.
3) The value of the lactate was significantly elevated, which was also associated with the deterioration of the alveolar capillary system.
4) The ultrastructual study revealed the striking alteration in the microcirculatory system in the alveo-capillary wall.
The transformed white blood cells were aggregated in the capillary and fused platelets were also aggregated in the vascular wall. The fragment of the endothelial cell lining was also discernible, suggesting the initial site of the membrane injury in the endothelial cells. The type II epithelial cells were also undergoing the degenerative changes which correlated with the decrease of the surfactant activity in virtue of the biochemical characterization.
