THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
L-ASCORBIC ACID METABOLISM IN ALLOXAN-DIABETIC RATS AND TUMOR-BEARING RATS
MASAYUKI KANDAYOSHITAKA OGAWAKIICHI HAYASHIKOUJI ITOUYUKIYA SAKAMOTO
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1965 Volume 11 Issue 1 Pages 45-47

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Abstract
1. The abnormally high rate of urinary excretion of L-ascorbic acid in alloxan-diabetic rats was found to be partially the result of a lowered rate of destruction of L-ascorbic acid in the liver caused by insulin deficiency.
2. The synthesis of L-ascorbic acid from D-glucuronolactone and the destruction of L-ascorbic acid were found to decrease in the liver of tumor-bearing rats.
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© THE VITAMIN SOCIETY OF JAPAN
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