STUDIES ON THE CHEMICAL PROPERTIES OF α-LIPOAMIDE (1, 2-DITHIOLANE-3-VALERAMIDE)

I. FORMATION OF 5-(2-THIACYCLOBUTYL) VALERAMIDE WITH POTASSIUM CYANIDE AND THE POSSIBILITY OF ITS ANALYTICAL APPLICATION

Abstract

1. Reaction of α-lipoamide with potassium cyanide in dilute ethanol was investigated. It was thereby found that α-lipoamide was converted to 5-(2-thiacyclobutyl) valeramide almost quantitatively with loss of sulfur.
2. 5-(2-thiacyclobutyl) valeramide has many advantageous points in its gaschromato-graphic behavior, such as sensitivity, reproducibility and retention time, as compared with those of α-lipoamide.
The conversion of α-lipoamde to 5-(2-thiacyclobutyl) valeramide, therefore, will be a very useful means for the determination of α-lipoamide.