Abstract
Safety examinations of thiamine monophosphate disulfide (TMPDS) was performed by chronic toxicity and teratological tests and obtained the following findings.
1. In the chronic toxicity test, TMPDS was administered to rats intraperitoneally in doses of 100 and 50mg/kg daily for six months. No significant differences among the groups were observed in the body weight gain, food intake, organ weights and hematological and histological findings.
2. In the teratological test, 500, 100 and 50mg/kg of TMPDS were administered intraperitoneally to gestated rats and mice every day from the 7th to 14th day of gestation. No effects of TMPDS was observed on both fetuses and new-horns from the mother animals.
