Abstract
Various O-acyl thiamine disulfides were parenterally given in rabbits, the retentivity in the blood was compared, and the following findings were obtained.
1. The proximate elimination rate constant and the biological half-life were calculated by treating reaction-kinetically the decreasing process of the blood total thiamine level to estimate the retentivity of each compound in the body by exact numerical values.
2. It was clarified that the retentivity obtained by this procedure had a correlation with the uptake by erythrocytes, determined in vitro.
3. Among the derivatives examined, O-butyrylthiamine disulfide was proved to be of value as a new thiamine derivative, in respect to the maintenance of the high blood level, stability, solubility and safty.
