Abstract
β-Ketovinyl thioether type thiamines and the related compounds have been examined on thiamine activity as well as thiamine liberation in vitro and in vivo. Sixteen compounds showed more or less vitamin activity, of which the most active ones were BD 108 and BD 81 with about 70% of the activity of thiamine HCI, while BD 101 and BD 142 showed no activity. BD 99, BD 108, and BD 112 with higher thiamine activity were converted into thiamine by incubation with glutathione. Urinary excretions of thiamine was significantly increased following intraperitoneal injection of these derivatives. A correlation was recognized between thiamine activity and urinary excretion of thiamine.
