THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
HISTOLOGICAL INVESTIGATIONS ON THE LIVER-DISTURBING ACTION OF 2-METHYL-4-AMINO-5-HYDROXYMETHYLPYRIMIDINE
YOSHITO NISHIZAWATEISUKE KODAMATOKUZO KOOKA
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JOURNAL FREE ACCESS

1957 Volume 3 Issue 4 Pages 309-321

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Abstract
1. OMP is found to have a liver-disturbing effect.
2. The toxicity of OMP is most effectively prevented by vitamin B6, but liver-protecting agents, as methionine and N-carbobenzoxy glutamylcholine, also have some effect even when administered alone.
3. The minimum disturbing dose of OMP is between 0.04 and 0.004mg/g.
4. The pyridoxine plus pyridoxamine content and the pyridoxal content of the liver are reduced when OMP is administered.
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© THE VITAMIN SOCIETY OF JAPAN
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