Abstract
1. The actions of ADS and DPN on the uteri of rabbits, the guts of guinea pigs and rabbits, and the bladders of guniea pigs were examined pharmacologically. Various organs of the animals which had been administered a large dose of DPN intravenously were also examined histologically.
2. Both ADS and DPN showed contracting effects on the uteri of rabbits and on the bladders of guinea pigs, and relaxing effects on the guts of guinea pigs and rabbits.
3. The contracting effect of ADS or DPN on the uteri of rabbits was not inhibited by atropine or PBM, but was decreased by PPV.
4. The relaxing effect of ADS or DPN on the guts of guinea pigs and rabbits was not influenced either by atropine or PBM. ADS and DPN did not inhibit the gut-contracting effect of histamine, ACH or BaCl2. The increase of the tonus of a rabbit's gut by PCP was easily relaxed by DPN.
5. Intravenous administration of a large dose of DPN to an animal produced vasodilatation and congestion in the lungs, spleen, liver, kidneys, suprarenal glands, ileum, caecum, stomach, testis and epididymis, and marked hemorrhages in some of the organs.
