THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
HISTOPATHOLOGICAL STUDIES ON THE LIVER, KIDNEY AND THYMUS OF CHICK EMBRYOS ADMINISTERED WITH HYDROXYMETHYLPYRIMIDINE
KEIZO TAKAHASHITOSHIAKI NAKAJIMASATORU KANAKI
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1959 Volume 5 Issue 3 Pages 178-187

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Abstract
OMP and pyridoxine were each injected into the white of fertile white Leghorn eggs and the liver, kidney and thymus of the chick embryos were histopathologically examined on the 12th, 15th and 18th day of incubation and the following results were obtained.
1. Findings in the Liver-In OMP groups, fat appearance was observed on the 12th and 15th day of incubation. It was not marked, when pyridoxine was combined with OMP. The fat appearance was recovered on the 18th day of incubation. Necrobiosis of the liver cells and capillary hyperemia were also marked in OMP groups. Fat appeared also in vitamin B6 group.
2. Findings in the Kidney-Hyperemia in glomeruli and regressive changes in the epithelia of the urinary tubules were observed in OMP groups.
3. Findings in the Thymus-In both OMP groups and vitamin B6 group, anisocytosis, non-stainability and nucleus pycnosis of thymicolymphatic cells were detected, whereas no atrophy of the organ was observed.
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