Abstract
Several antibiotics inhibited D-amino acid oxidase of hog kidney. Among them, penicilline, p-amino salicylic acid, sulfanilamide and oxytetracycline inhibited the enzymic activity by competition with either FAD or D-alanine. Chlortetracycline, tetracycline and erythromycin inhibited the enzymic activity by competition with FAD but not with D-alanine. Chloramphenicol and isonicotinic acid hydrazide inhibited the enzymic activity by competition with D-alanine rather than with FAD. Streptomycin had little effect on the enzymic activity.
The mechanism of the symptoms resembling those of ariboflavinosis following administrations of antibiotics was discussed to some extent. A possibility that binding of certain antibiotics to a flavoenzyme by competition with FAD might result in ariboflavinosis was suggested.
