Abstract
When free pyrimidine base, uracil is administered to normal healthy animals, not only the decrease of RNA in the liver, but also the decrease of FAD in the liver and kidney due to the disturbance of riboflavin biosynthesis of intestinal microorganisms and of FAD formation in the liver and kidney resulted, and the animal growth was suppressed and the blood sugar level rose. As the incorporation of uracil into nucleotides took place in the regenerating liver, uracil is to be considered to be acting effectively in the case of liver damage. The authors examined and studied the action of uracil as a free pyrimidine base and also on its concern in the riboflavin metabolism.
