2003 Volume 49 Issue 3 Pages 195-200
The presence of a significant amount of 9, 11-conjugated linoleic acid (CLA, 9, 11-18%2) was confirmed in the liver and plasma lipids of rats fed a 1% (w/w % of diet) eleo-stearic acid (ESA, 9, 11, 13-18 e 3 ) diet for 4 wk, The chemical structure of the 9, 11-CLA apparent in the tissue lipids was identified by gas chromatography-electron impact mass spectrometry after its conversion to a 4, 4-dimethyloxazoline derivative. The concentration of CLA in the total fatty acids of the liver and plasma lipids reached to about 1% for each in the CLA-supplemented rats, while reaching 3.2% and 2.5%, respectively, in the ESA-supplemented rats, The results suggest that α-ESA is metabolized partially to CLA via a delta 13-saturation reaction in the rat. Some biological activities observed in α-ESA-fed animals may be ascribed also to CLA that is formed from ESA in the body.
