Two cases of nevoid hyperkeratosis of nipple and areola

Abstract

Case1 : A 37-year-old woman who was pregnant noticed brown nodules and papules on both sides of the nipples and areolas. Case2 : A 30-year-old woman noticed the asymptomatic thickening and pigmentation of the nipples and areolas.We diagnosed as nevoid hyperkeratosis of nipple and areola（NHNA）by the clinical and histopathological findings in both cases. NHNA, which is more common in women of childbearing age, is a relatively rare disease characterized by hyperkeratosis and papillomatosis of the areola and nipple. It was first introduced by Tauber in 1923, and classified into three types as hyperkeratosis of nipple and areola（HNA）by Franckel in 1938. The pathogenesis is still unknown, and the typical treatment has not been established. We’d like to report two cases of NHNA, and discuss about its clinical and histopathological features and differential diagnosis.