Abstract
This patient was a 55-year-old man with a blackish brown papillary nodule that appeared in the umbilical region 5 months prior to the initial examination and gradually increased in size. Seborrheic keratosis was diagnosed at another hospital and treatment was initiated; however, there was no improvement and the patient was referred to our department. A blackish brown papillary nodule measuring 10 mm was noted in the umbilical region. Histopathological findings revealed koilocytosis as a fenestration around the nuclei of epidermal keratinocytes. was negative using K1H8 and 4C4 Anti- human papillomavirus (HPV) monoclonal antibody immunostaining. However, HPV6/11 probe was positive with in situ hybridization. As such, condyloma acuminatum was diagnosed. Electrocautery and liquid nitrogen cryotherapy were performed on the nodule. The nodule disappeared in 3 months after combined topical treatment with active vitamin D3 ointment and imiquimod. Condyloma acuminatum is a sexually transmitted disease that commonly occurs around the genital area and the anus. There are few cases of occurrence at other sites and, there is no report of condyloma acuminatum occurring in the umbilical region. Examples of skin tumors in the umbilical region include seborrheic keratosis, basal cell carcinoma, and metastatic skin cancer. However, condyloma acuminatum has rarely been considered as differential diagnosis in this region. We report this case, to shed some light on the diagnosis, treatment, and prevention of infection.
