Effects of enamel matrix derivatives on periodontal tissue regeneration

Abstract

To confirm the effectiveness of the use of an enamel matrix derivative (EMD) for periodontal tissue regeneration, we clinically compared a flap operations done with EMD application (EMD group) and without (control group). At each observation point, gingival recession, pocket depth, and the clinical attachment level were lower in the EMD group than in the controls, and significant differences were observed in all parameters at all observation times except for gingival recession 3 months after the operation. In particular, the clinical attachment level as a parameter of periodontal tissue destruction most markedly differed between the two groups at each observation point, confirming the effectiveness of EMD for periodontal tissue regeneration.