Wound healing on palatine mucosa in the type 2 diabetes mellitus model rats
2011 Volume 45 Issue 1 Pages 37-53
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2011 Volume 45 Issue 1 Pages 37-53
We analyzed histological changes during spontaneous healing in palatine mucosa lesions and examined whether there were any differences in healing between GK (diabetes group) and normal Wistar (control group) rats. Forty-three 8-week-old male rats (21 in each group) were used in this study. We created a cylindrical lesion 1.5mm in diameter in the palatine mucosa of the right maxillary first molar by removing all of the soft tissue. One Wistar rat was not given a lesion and was observed about normal histological structures. Immediately and one day after surgery, the experimental cavities of both groups were filled with blood clots. The mucosal epithelium converged on day 3 after surgery in the control group and on day 7 in the diabetes group. Granulation tissue was seen on day 5 in the control group and on day 7 in the diabetes group. Collagen fibers appeared on day 7 in the controls and on day 14 in the diabetes group. We observed the formation of sequestrum on days 14 and 28 in one of six rats in the control group and five of six in the diabetes group. Our results demonstrate that wound healing was delayed in the diabetes group compared with the controls. Furthermore, sequestrum formation occurred at a higher rate in the diabetes group.
