Effects of Porphyromonas gingivalis on oxidant stress of human bone marrow cells in vitamin E
2019 Volume 53 Issue 2 Pages 133-139
Details
2019 Volume 53 Issue 2 Pages 133-139
α‐Tocopherol is the most physiologically active member of the vitamin E family, and its role as an antioxidant in various metabolic processes is widely recognized. However, vitamin E is often deficient in the human body, and only a few reports are available on the effects of periodontal disease on oxidative stress under vitamin E deficient conditions. We investigated the influence of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on oxidative stress in human bone marrow mesenchymal cells (BMMCs) at low concentrations of α‐tocopherol. We found an increase in H2O2 production at multiplicity of infection (MOI) of 100 and 1000 at earlier time points and with a concomitant decrease in SOD production. Catalase was produced regardless of P. gingivalis. These results suggest that P. gingivalis reduces the production of some antioxidant enzymes at low concentrations of α‐tocopherol and affects the initial cell proliferation and H2O2 production. (J Osaka Dent Univ 2019; 53: 133‐139)
