High-power light emitting diode irradiation promotes hard tissue differentiation of human dental pulp stem cells

Abstract

Antibacterial photodynamic therapy using light emitting diodes (LEDs) has been shown effective against periodontitis and peri-implantitis. In recent years, there has been research on the application of photodynamic therapy using LEDs in regenerative medicine. It uses "light" as a method of host activation, which is one of the three elements of regeneration. We reported that irradiation of human periodontal ligament stem cells with high-power red LEDs under appropriate irradiation conditions promotes hard tissue differentiation. It has also been confirmed that LEDs can be applied to bone marrow mesenchymal cells and osteoblasts to promote hard tissue differentiation. We investigated cell proliferation and hard tissue differentiation of human dental pulp stem cells, as one of the cell sources of undifferentiated mesenchymal stem cells, in order to clarify the effect of high-power red LEDs on hard tissue regeneration. (J Osaka Dent Univ 2022; 56: 203-208)